| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-801 | |
| Phytochemical name or plant extracts | 4-vinylphenol (4VP) | |
| PMID | 26053458 | |
| Literature evidence | Nevertheless, the present study reported the novel anti-angiogenic activities of 4VP which was firstly isolated from the aqueous extract of a Chinese medicinal herb Hedyotis diffusa. | |
| IUPAC name | 4-ethenylphenol | |
| Phytochemicals’ class or type of plant extracts | Styrene metabolite | |
| Source of phytochemicals or plant Extracts | Hedyotis diffusa | |
| Geographical availability | Andaman Is., Assam, Bangladesh, Borneo, Cambodia, China South-Central, China Southeast, East Himalaya, Hainan, India, Japan, Jawa, Korea, Lesser Sunda Is., Malaya, Myanmar, Nansei-shoto, Nepal, Nicobar Is., Philippines, Sri Lanka, Sumatera, Taiwan, Thailand, Vietnam | |
| Plant parts | Whole plant | |
| Other cancers | Breast cancer | |
| Target gene or protein | PI3K/AKT, p38 MAPK, NF-κB | |
| Gene or Protein evidence | Investigation of the signal transduction revealed that 4VP down-regulated PI3K/AKT and p38 MAPK. Besides, 4VP interfered with the phosphorylation of ERK1/2, the translocation and expression of NFkappaB. | |
| Target pathways | PI3K/AKT, ERK and p38 signaling pathway | |
| IC50 | NA | |
| Potency | In addition, the blood vessel number and tumor size were reduced by intraperitoneal 4VP (0.2-2 mg/kg) in 4T1 breast tumor-bearing BALB/c mice, with doxorubicin as positive control. | |
| Cell line/ mice model | C57BL/6 mice | |
| Additional information | 4-VP caused a dose-dependent increase in serum SDH and mild hepatocellular swelling. It caused an increase in cell number and lactate dehydrogenase activity in BALF. | |
| PubChem ID | 62453 | |
| Additional PMIDs | 12371665 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:752440-1 | |
| Safety | NA |