| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1721 | |
| Phytochemical name or plant extracts | 4-hydroxyisophthalic acid (4-HIPA) | |
| PMID | 32607952 | |
| Literature evidence | In the present study we have evaluated the antiproliferative potential of 4-hydroxyisophthalic acid (4-HIPA), which is a novel antioxidant compound isolated from the roots of the aqueous extract of Decalepis hamiltonii. 4-HIPA was screened in vitro against human breast cancer cell lines MCF-7, MDA-MB-468 and normal human breast epithelial cell MCF-10, and demonstrated that human breast cancer cell lines, in contrast to MCF-10, are sensitive to 4-HIPA .4-HIPA showed marked reduction in cell viability and short-term proliferation assays in these cells. | |
| IUPAC name | 4-hydroxybenzene-1,3-dicarboxylic acid | |
| Phytochemicals’ class or type of plant extracts | Carboxylic acid | |
| Source of phytochemicals or plant Extracts | Decalepis hamiltonii | |
| Geographical availability | India | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | This study is valuable as 4-HIPA exhibits antiproliferative potential that can be exploited in the development of anticancer drugs. Our in vivo results established that treatment with 4-HIPA reduced the tumorigenesis by promoting apoptosis in EAT-bearing mice. | |
| Cell line/ mice model | MCF-7, MDA-MB-468, MCF-10 | |
| Additional information | Results of the long-term colony formation and scratch assay further reaffirmed that 4-HIPA inhibited the growth and proliferation in breast cancer cells. | |
| PubChem ID | 12490 | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | 4-HIPA was screened in vitro against human breast cancer cell lines MCF-7, MDA-MB-468 and normal human breast epithelial cell MCF-10, and demonstrated that human breast cancer cell lines, in contrast to MCF-10, are sensitive to 4-HIPA . |