| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1701 | |
| Phytochemical name or plant extracts | 4',6'-dihydroxy-2',4-dimethoxy-5'-(2″-hydroxybenzyl)dihydrochalcone | |
| PMID | 31772936 | |
| Literature evidence | The reduction of mitochondrial transmembrane potential (staining with 3,3'-dihexyloxacarbocyanine iodide, DiOC6, employing a flow cytometer) was established in the compound 1-treated cells. | |
| IUPAC name | 3-(4-methoxyphenyl)-1-{2,4,6-trihydroxy-3-[(2-hydroxyphenyl)methyl]phenyl}propan-1-one | |
| Phytochemicals’ class or type of plant extracts | Chalcone | |
| Source of phytochemicals or plant Extracts | Cyathostemma argenteum | |
| Geographical availability | Assam, Bangladesh, Borneo, China South-Central, Jawa, Malaya, Myanmar, Sumatera, Thailand, Vietnam | |
| Plant parts | Leaves and twigs | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 3, Caspase 8, Caspase 9, ATM, ATR | |
| Gene or Protein evidence | Compound 1 induced caspase-3, caspase-8, and caspase-9 activities in both cell lines, as has been determined by specific colorimetric substrates and a spectrophotometric microplate reader which indicated the involvement of both the extrinsic and intrinsic pathways. Compound 1 also induced cell cycle arrest via increased atm and atr checkpoint gene expression levels and BioMed Research International 15 inhibited the EGFR/MAPK survival pathway to promote cell apoptosis | |
| Target pathways | In conclusion, compound 1 induced MDA-MB-231 and MCF-7 cell apoptosis via intrinsic, extrinsic, and ER stress pathways, whereas it ameliorated the EGFR/MAPK pathway in the MCF-7 cell line. | |
| IC50 | 232.7 ± 3.9 μM against MDA-MB-231 88.3 ± 5.4 μM against MCF-7 | |
| Potency | Consequently, it is believed that compound 1 could be effectively developed for cancer treatments. | |
| Cell line/ mice model | MDA-MB-231 and MCF-7 | |
| Additional information | Calcium ion levels in mitochondrial and cytosolic compartments increased in compound 1-treated cells as detected by Rhod-2AM and Fluo-3AM intensity, respectively, indicating the involvement of the endoplasmic reticulum (ER) stress pathway. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:72692-1 | |
| Safety | NA |