| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-246 | |
| Phytochemical name or plant extracts | 3-O-α-L-arabinosyl oleanolic acid (3-O-L-AO) | |
| PMID | 34058937 | |
| Literature evidence | This study was conducted to determine the anti-cancer activity of 3-O-α-L-arabinosyl oleanolic acid (3-O-L-AO), a triterpenoid saponin, isolated from the leaves of Schumacheria castaneifolia Vahl in breast cancer stem cells (bCSCs) grown in hypoxia. | |
| IUPAC name | (4aS,6bR,10S,12aR,14bS)-2,2,6a,6b,9,9,12a-heptamethyl-10-{[(2S,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxy}-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid saponin | |
| Source of phytochemicals or plant Extracts | Schumacheria castaneifolia | |
| Geographical availability | Sri Lanka | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, p53, Survivin, HIF-1α, HIF-2α | |
| Gene or Protein evidence | Treatment of bCSCs with 3-O-L-AO resulted in a significant up-regulation of Bax and p53 and a significant down-regulation of survivin, HIF-1α and HIF-2α. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Collectively, the results obtained indicated that 3-O-L-AO can be considered as a new anti-cancer agent to target chemo- and radio-therapy-resistant bCSCs. | |
| Cell line/ mice model | NA | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:317342-1 | |
| Safety | NA |