| Properties | Information |
|---|---|
| PhytoCAT-ID | PhytoCAT-1593 |
| Phytochemical name or plant extracts | 3-(4-methoxyphenyl) quinolin-4(1H)-one |
| PMID | 32944400 |
| Literature evidence | Here, we aimed to find novel efficient antiangiogenic molecules targeting vascular endothelial growth factor A (VEGFA ) at the transcriptional level to treat triple-negative breast cancer (TNBC). |
| IUPAC name | 3-(4-methoxyphenyl)-1H-quinolin-4-one |
| Phytochemicals’ class or type of plant extracts | Flavonoid |
| Source of phytochemicals or plant Extracts | NA |
| Geographical availability | NA |
| Plant parts | NA |
| Other cancers | Breast cancer |
| Target gene or protein | SerRS mRNA, VEGFA |
| Gene or Protein evidence | In TNBC cells, MEQ treatment resulted in increased SerRS mRNA (P < 0.001) and protein levels and downregulated VEGFA production. |
| Target pathways | NA |
| IC50 | NA |
| Potency | Our findings suggested that the MTA2/SerRS/VEGFA axis is a drug-treatable anti-angiogenic target, and MEQ is a promising anti-tumor molecule that merits further investigation for clinical applications. |
| Cell line/ mice model | MDA-MB-231, 4T1 / BALB/c mice |
| Additional information | NA |
| PubChem ID | 279953 |
| Additional PMIDs | NA |
| Additional sources of information | NA |
| Safety | NA |