| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-756 | |
| Phytochemical name or plant extracts | 3β-trans-cinnamoyloxy-2α-hydroxy-urs-12-en-28-oic acid (CHUA) | |
| PMID | 25521501 | |
| Literature evidence | A novel triterpenoid, named 3β-trans-cinnamoyloxy-2α-hydroxy-urs-12-en-28-oic acid (CHUA), was one of the main components of apple peels and showed potent in vitro antitumor activity against human tumor cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid | |
| Source of phytochemicals or plant Extracts | Malus pumila | |
| Geographical availability | Afghanistan, Kazakhstan, Kirgizstan, Pakistan, Tadzhikistan, Uzbekistan, Xinjiang | |
| Plant parts | Peels | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, Bcl-2, cyt-c, Bcl-xL | |
| Gene or Protein evidence | The data showed that the expression of pro-apoptotic Bax and the release of cytochrome c began to increase in response to CHUA treatment, whereas the expression levels of anti-apoptotic Bcl-2 and Bcl-XL were down-regulated after 12 h of treatment. | |
| Target pathways | Mitochondrial and caspase-independent pathways | |
| IC50 | 2.57 ± 0.11 μM against MDA-MB-231 5.45 ± 0.23 μM against MCF-7 | |
| Potency | The results suggested that CHUA significantly inhibited the cell growth and proliferation of MDA-MB-231, MCF-7, and A549 cell lines with IC50 values of 2.57 ± 0.11, 5.45 ± 0.23, and 6.37 ± 0.29 μM, respectively. | |
| Cell line/ mice model | MDA-MB-231, MCF-7, HepG2, Caco-2, HeLa, A549/ old female nude mice (Balb/c-nu/nu) | |
| Additional information | Interestingly, z-VAD-fmk and z-DEVD-fmk augmented cell death after CHUA treatment. Other protease(s) different from caspase-3 might be responsible for the degradation of PARP. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:726282-1 | |
| Safety | NA |