| Properties | Information |
|---|---|
| PhytoCAT-ID | PhytoCAT-1900 |
| Phytochemical name or plant extracts | 3β-hydroxy-30-(4-phenyl-1-piperazinyl)olean-12-ene-11,30-dione |
| PMID | 28599090 |
| Literature evidence | A series of novel glycyrrhetic acid derivatives were synthesized and evaluated for their VEGFR2 inhibitory activity as well as their antiproliferative properties against four cancer cell lines (MCF-7, HeLa, HepG2, and A549). |
| IUPAC name | 3β-hydroxy-30-(4-phenyl-1-piperazinyl)olean-12-ene-11,30-dione |
| Phytochemicals’ class or type of plant extracts | Triterpenoid |
| Source of phytochemicals or plant Extracts | NA |
| Geographical availability | NA |
| Plant parts | NA |
| Other cancers | Breast cancer, Cervical cancer, Lung cancer, Liver cancer |
| Target gene or protein | NA |
| Gene or Protein evidence | NA |
| Target pathways | NA |
| IC50 | 1.08 μm against MCF-7 |
| Potency | NA |
| Cell line/ mice model | MCF-7, HeLa, HepG2,A549 |
| Additional information | (3β-hydroxy-30-(4-phenyl-1-piperazinyl)olean-12-ene-11,30-dione) also showed the most potent inhibitory activity against VEGFR2 tyrosine kinase, with an IC50 value of 0.35 μm. |
| PubChem ID | NA |
| Additional PMIDs | NA |
| Additional sources of information | NA |
| Safety | NA |