| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2179 | |
| Phytochemical name or plant extracts | 3β,6β,16β-trihydroxy-lup-20(29)-ene | |
| PMID | 25086656 | |
| Literature evidence | The apoptosis induced by TTHL was accompanied by increased levels of both cleaved caspase-9 and intracellular ROS. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid | |
| Source of phytochemicals or plant Extracts | Combretum leprosum | |
| Geographical availability | Argentina Northeast, Bolivia, Brazil North, Brazil Northeast, Brazil Southeast, Brazil West-Central, Paraguay | |
| Plant parts | Flowers | |
| Other cancers | Breast cancer, Colorectal cancer, Bladder cancer, Liver cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 1.36 μg/mL against MCF-7 | |
| Potency | The natural triterpene 3β,6β,16β-trihydroxy-lup-20(29)-ene obtained from the flowers of Combretum leprosum induces apoptosis in MCF-7 breast cancer cells | |
| Cell line/ mice model | MRC5, MCF-7, HepG2, T24, HCT116, HT29, CACO-2 | |
| Additional information | Taken together, the results suggest that TTHL forms covalent adducts with cellular macromolecules, potentially disrupting cellular function and triggering apoptosis. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:170228-1 | |
| Safety | NA |