| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-155 | |
| Phytochemical name or plant extracts | 3,3'-di-O-methylquercetin | |
| PMID | 22418930 | |
| Literature evidence | Methylated quercetins isolated from Inula viscosa have improved anticancer and antimicrobial properties compared with other flavonoids and are promising as potential anticancer and antimicrobial agents. | |
| IUPAC name | 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-methoxychromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Inula viscosa | |
| Geographical availability | Albania, Algeria, Azores, Baleares, Bulgaria, Canary Is., Corse, Cyprus, East Aegean Is., Egypt, France, Greece, Italy, Kriti, Lebanon-Syria, Libya, Madeira, Morocco, Palestine, Portugal, Sardegna, Sicilia, Sinai, Spain, Tunisia, Turkey, Turkey-in-Europe, Yugoslavia | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Larynx cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 10.11 µg/mL against MCF-7 | |
| Potency | 3,3'-di-O-Methylquercetin and 3-O-methylquercetin showed selective antiproliferative activity against MCF-7 cells, with IC(50) values of 10.11 and 11.23 µg/mL, respectively. | |
| Cell line/ mice model | MCF-7, Hep-2, Vero cell | |
| Additional information | Our results report for the first time the antiproliferative activity of naturally occurring 3,3′-di-O-methylquercetin. It seems that the presence of additional methyl group on position 3' did not improve the antiproliferative activity of 3,3′-di-O-methylquercetin compared with 3-O-methylquercetin. | |
| PubChem ID | 5316900 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:226187-1 | |
| Safety | NA |