| Properties | Information |
|---|---|
| PhytoCAT-ID | PhytoCAT-1586 |
| Phytochemical name or plant extracts | 3,3',4,4',5,5'-hexahydroxystilbene (M8) |
| PMID | 18434081 |
| Literature evidence | Cytotoxic activity of 3,3',4,4',5,5'-hexahydroxystilbene against breast cancer cells is mediated by induction of p53 and downregulation of mitochondrial superoxide dismutase. |
| IUPAC name | 5-[2-(3,4,5-trihydroxyphenyl)ethenyl]benzene-1,2,3-triol |
| Phytochemicals’ class or type of plant extracts | Stilbenoid |
| Source of phytochemicals or plant Extracts | NA |
| Geographical availability | NA |
| Plant parts | NA |
| Other cancers | Breast cancer |
| Target gene or protein | p53, MnSOD |
| Gene or Protein evidence | Activation of caspase-9 and caspase-3 was connected with loss of mitochondrial potential and increase of p53, which could have an impact on downregulation of mitochondrial superoxide dismutase (MnSOD) seen in our experiments. |
| Target pathways | NA |
| IC50 | 8.53 µM against ZR-75-1 25.5 µM against MDA-MB-231 0.846 µM against T47D |
| Potency | Since cancer cells are usually under permanent oxidative stress, additional increased ROS generation as a result of the interaction of M8 with the mitochondrial respiratory chain and a decrease in oxidative defense can therefore be a promising method for selective elimination of cancer cells. |
| Cell line/ mice model | ZR-75-1, MDA-MB-231, T47D |
| Additional information | Using a specific Hoechst/propidium iodide double staining method, we found that M8 was able to induce apoptosis in concentrations significantly lower than those of RV. In addition, M8 arrested cells in the S phase and totally depleted cells in the G2-M phase of the cell cycle (143% and 0% of control after treatment with 12.5 microM M8, respectively). |
| PubChem ID | 53395178 |
| Additional PMIDs | 17065056 |
| Additional sources of information | NA |
| Safety | NA |