| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-382 | |
| Phytochemical name or plant extracts | 2alpha-hydroxyursolic acid | |
| PMID | 17488026 | |
| Literature evidence | Among the compounds isolated, 2alpha-hydroxyursolic acid, 2alpha-hydroxy-3beta-{[(2E)-3-phenyl-1-oxo-2-propenyl]oxy}olean-12-en-28-oic acid, and 3beta-trans-p-coumaroyloxy-2alpha-hydroxyolean-12-en-28-oic acid showed higher antiproliferative activity toward HepG2 cancer cells. | |
| IUPAC name | (1S,2R,4aS,6aR,6aS,6bR,8aR,10R,11R,12aR,14bS)-10,11-dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid | |
| Source of phytochemicals or plant Extracts | Cunila lythrifolia | |
| Geographical availability | Mexico Central, Mexico Gulf, Mexico Northeast, Mexico Southwest | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer, Liver cancer, Colon cancer | |
| Target gene or protein | NF-κB | |
| Gene or Protein evidence | These results suggest that 2alpha-hydroxyursolic acid has antiproliferative activities against MCF-7 cells and capabilities inhibiting NF-kappaB activation induced by TNF-alpha partially by suppressing proteasome activities. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | EC50= 4.7 ± 1.7 μM against MCF-7 | |
| Cell line/ mice model | HepG2, MCF-7, Caco-2 | |
| Additional information | Ursolic acid, 2alpha-hydroxyursolic acid, and 3beta-trans-p-coumaroyloxy-2alpha-hydroxyolean-12-en-28-oic acid exhibited higher antiproliferative activity against MCF-7 cancer cells. | |
| PubChem ID | 6918774 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:446315-1 | |
| Safety | NA |