| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1577 | |
| Phytochemical name or plant extracts | 2a,3ß-dihydroxylup-20(29)-ene-27,28-dioic acid | |
| PMID | 17464428 | |
| Literature evidence | Fractions containing mainly betulin, lupenone, 3beta-hydroxylup-20(29)-ene-27,28-dioic acid, and 2alpha,3beta-dihydroxylup-20(29)-ene-27,28-dioic acid showed more activity than crude extracts. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid | |
| Source of phytochemicals or plant Extracts | Ampelozizyphus amazonicus Ducke | |
| Geographical availability | Brazil North, Colombia, French Guiana, Guyana, Peru, Suriname, Venezuela | |
| Plant parts | Stem | |
| Other cancers | Breast cancer, Skin cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | 2alpha,3beta-dihydroxylup-20(29)-ene-27,28-dioic acid exhibited cytotoxicity against both SKBR-3 human adenocarcinoma and C-8161 human melanoma tumor cell lines (>0.1 mg/mL). | |
| Cell line/ mice model | SKBR-3, C-8161 | |
| Additional information | A. amazonicus extracts contain potential compounds for use as chemoprophylactic agents against T. cruzi. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:11511-2 | |
| Safety | NA |