| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-746 | |
| Phytochemical name or plant extracts | 27-hydroxybullatacin | |
| PMID | 10395501 | |
| Literature evidence | Two novel acetogenins, annoglaxin and 27-hydroxybullatacin, from Annona glabra. | |
| IUPAC name | (2S)-4-[(2R,13R)-13-[(2R,5R)-5-[(2R,5R)-5-[(1S,4S)-1,4-dihydroxyundecyl]oxolan-2-yl]oxolan-2-yl]-2,13-dihydroxytridecyl]-2-methyl-2H-furan-5-one | |
| Phytochemicals’ class or type of plant extracts | Annonaceous acetogenins | |
| Source of phytochemicals or plant Extracts | Annona glabra | |
| Geographical availability | Bahamas, Belize, Brazil North, Brazil Northeast, Brazil South, Brazil Southeast, Cameroon, Cayman Is., Central American Pac, Colombia, Congo, Costa Rica, Cuba, Dominican Republic, Ecuador, El Salvador, Florida, French Guiana, Gabon, Gambia, Guatemala, Guinea, Guinea-Bissau, Gulf of Guinea Is., Guyana, Haiti, Honduras, Ivory Coast, Jamaica, Leeward Is., Liberia, Mexico Gulf, Mexico Northeast, Mexico Southeast, Mexico Southwest, Netherlands Antilles, Nicaragua, Nigeria, Panamá, Puerto Rico, Senegal, Sierra Leone, Southwest Caribbean, Suriname, Trinidad-Tobago, Venezuela, Venezuelan Antilles, Windward Is., Zaïre | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer, Kidney cancer, Prostate cancer, Pancreatic cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | 1 presents unusual features of an OH at C-8 and a carbonyl at C-12 and, while less potent than 2, shows interesting selectivity for the human breast carcinoma (MCF-7) cell line. | |
| Cell line/ mice model | MCF-7, A-498, PC-3, PACA-3 | |
| Additional information | Compound 2 was at least 100 000 times more potent than adriamycin against the human kidney carcinoma (A-498), prostate carcinoma (PC-3), and pancreatic carcinoma (PACA-2) cell lines in our panel of six human solid tumor cell lines. | |
| PubChem ID | 10722779 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:72208-1 | |
| Safety | LC50 = 7.8 × 10-4 μg/mL |