| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-4 | |
| Phytochemical name or plant extracts | 23-O-acetylcimigenol-3-O-β-D-xylopyranoside | |
| PMID | 20564500 | |
| Literature evidence | The present study was carried out to investigate the antitumor activity of five cycloartane triterpenoids isolated from Cimicifuga yunnanensis on the breast cancer cell line MCF7 and its corresponding drug resistant subline R-MCF7, including cimigenol-3-O-β-D-xylopyranoside (compound 1), 25-O-acetylcimigenol-3-O-β-D-xylopyranoside (compound 2), 25-chlorodeoxycimigenol-3-O-β-D-xylopyranoside (compound 3), 25-O-acetylcimigenol-3-O-α-L-arabinopyranoside (compound 4) and 23-O-acetylcimigenol-3-O-β-D-xylopyranoside (compound 5). | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Cycloartane triterpenoid | |
| Source of phytochemicals or plant Extracts | Cimicifuga yunnanensis | |
| Geographical availability | China North-Central, China South-Central | |
| Plant parts | Rhizome | |
| Other cancers | Breast cancer | |
| Target gene or protein | p53, Bax, Caspase 7 | |
| Gene or Protein evidence | The results of RT-PCR showed that compounds 2-5 increased the expression of p53 and bax, which led to the loss of mitochondrial potential and then resulted in the activation of caspase-7. | |
| Target pathways | p53-dependent mitochondrial pathway. | |
| IC50 | 39.13 ± 1.52 µg/mL against MCF-7 59.75 ± 1.13 µg/mL against R-MCF-7 | |
| Potency | The results showed that compounds 2-5 have relatively high antitumor activity on both MCF7 and R-MCF7 cells. Compound 5 is 23-O-acetylcimigenol-3-O-β-D-xylopyranoside. | |
| Cell line/ mice model | MCF-7, R-MCF-7 | |
| Additional information | Compound 2 and compound 5 have been reported to have anti-liver cancer activity, and this study displayed that they also have anti-breast cancer activity. Compound 5 is 23-O-acetylcimigenol-3-O-β-D-xylopyranoside. These findings collectively demonstrated that compounds 2-5 induced apoptosis of MCF7 via p53-dependent mitochondrial pathway. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:1002882-1 | |
| Safety | NA |