| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1198 | |
| Phytochemical name or plant extracts | 23,24-Dihydrocucurbitacin B | |
| PMID | 17681423 | |
| Literature evidence | In this study, DHCB, isolated from roots of Trichosanthes kirilowli which is a traditional Chinese herb medicine used as treatments for cancer and other diseases, has been found to inhibit the proliferation of human cancer cell lines Bcap37, HeLa, SW620, SMMC-7721, K562 and MCF-7 in a dose- and time-dependent manner, and induce apoptosis in human breast cancer cell line Bcap37 at low concentration. | |
| IUPAC name | [(6R)-6-[(2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxoheptan-2-yl] acetate | |
| Phytochemicals’ class or type of plant extracts | Alpha-hydroxy ketone | |
| Source of phytochemicals or plant Extracts | Trichosanthes kirilowli | |
| Geographical availability | Cambodia, China North-Central, China Southeast, Inner Mongolia, Japan, Korea, Laos, Nansei-shoto, Vietnam | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Flow cytometric analysis revealed that at the lower dose of 1.8 and 3.6muM, DHCB-induced cancer cell lines death via an apoptotic process rather than necrotic one, whereas, the higher dose of 8.9, 17.9 and 35.7muM induced cell death via the necrotic process. | |
| Cell line/ mice model | Bcap37, HeLa, SW620, SMMC-7721, K562, MCF-7 | |
| Additional information | Cell-cycle analysis demonstrated DHCB induction of G(2)/M phase cell-cycle arrest and apoptosis. The overall results suggest that DHCB might have the therapeutic value against human cancer cell lines, especially the breast cancer cell lines. | |
| PubChem ID | 267250 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:294222-1 | |
| Safety | NA |