| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-956 | |
| Phytochemical name or plant extracts | 20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol [20(S)-25-OCH3-PPD] | |
| PMID | 17266624 | |
| Literature evidence | Isolation, structural determination, and evaluation of the biological activity of 20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol [20(S)-25-OCH3-PPD], a novel natural product from Panax notoginseng. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ginsenoside | |
| Source of phytochemicals or plant Extracts | Panax notoginseng | |
| Geographical availability | Vietnam | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer, Pancreatic Cancer, Lung Cancer, Prostate Cancer, Glioma | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 13.5 uM against MCF-7 18.2 uM against MDA-MB-468 | |
| Potency | In regard to cytotoxicity, the IC50 values of 20(S)-25-OCH3-PPD for most cell lines were in the lower microM range, a 5-15-fold greater cytotoxicity relative to 20(S)-PPD and a 10-100-fold increase over Rg3. | |
| Cell line/ mice model | MCF-7, MDA-MB-468, A172 , T98G, HPAC, Panc-1, A549, H1299, H358, H838, LNCaP, PC3 | |
| Additional information | The biological activities of 20(S)-25-OCH3-PPD and its known analogs, 20(S)-PPD and Rg3, were evaluated in 12 human cancer cell lines. In all cell lines, the order of cytotoxicity of the test compounds was 20(S)-25-OCH3-PPD >> 20(S)-PPD >> Rg3. 20(S)-25-OCH3-PPD also induced apoptosis and cell cycle arrest in the G1 phase, and inhibited proliferation in breast cancer cell lines, demonstrating its potent biological effects. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:91521-1 | |
| Safety | NA |