| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-337 | |
| Phytochemical name or plant extracts | 2-methoxy-1, 4-naphthoquinone | |
| PMID | 33576213 | |
| Literature evidence | CONCLUSION: Our findings indicate the ability of MNQ to inhibit the glycolytic activities as well as glycolysis-related molecules in MDA-MB-231 cells, suggesting the potential of MNQ to be further developed as an effective anticancer agent against TNBC cells. | |
| IUPAC name | 2-methoxynaphthalene-1,4-dione | |
| Phytochemicals’ class or type of plant extracts | Quinone | |
| Source of phytochemicals or plant Extracts | Impatiens balsamina | |
| Geographical availability | India, Sri Lanka | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | GLUT1, AKT | |
| Gene or Protein evidence | Remarkably, the expressions of GLUT1 and Akt molecules decreased in MNQ-treated cells, suggesting that the inhibition of glycolysis by MNQ is GLUT1-dependent and possibly mediated by the Akt signaling pathway. | |
| Target pathways | Akt signaling pathway | |
| IC50 | 29 µM against MDA-MB-231 | |
| Potency | Our findings indicate the ability of MNQ to inhibit the glycolytic activities as well as glycolysis-related molecules in MDA-MB-231 cells, suggesting the potential of MNQ to be further developed as an effective anticancer agent against TNBC cells. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | The percentage of glucose uptake into the cells and lactate production decreased significantly after treatment with MNQ as compared to untreated cells. | |
| PubChem ID | 16871 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:373978-1 | |
| Safety | NA |