| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-176 | |
| Phytochemical name or plant extracts | 2-hydroxy-6-tridecylbenzoic acid | |
| PMID | 32779484 | |
| Literature evidence | These findings may provide a novel mechanism of the 2-hydroxy-6-tridecylbenzoic acid as a molecular-targeted therapeutic drug for TNBC patients. | |
| IUPAC name | 2-hydroxy-6-tridecylbenzoic acid | |
| Phytochemicals’ class or type of plant extracts | Hydroxybenzoic acid | |
| Source of phytochemicals or plant Extracts | Ginkgo biloba | |
| Geographical availability | China Southeast | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | E-cadherin, N-cadherin, Vimentin, Snail, MMP2, MMP9 | |
| Gene or Protein evidence | 2-hydroxy-6-tridecylbenzoic acid inhibited cells migration and invasion as well as EMT with the increase of E-cadherin expression accompanied by the decrease of N-cadherin, Vimentin, Snail, MMP-2 and MMP-9 expression. | |
| Target pathways | AMPK signaling pathway | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MDA-MB-231, 4 T1 | |
| Additional information | The inhibition was further demonstrated by the enhancement of cytochrome P450 (CYP) 1B1 expression through the activation of AMP activated protein kinase (AMPK) in MDA-MB-231 and 4 T-1 cells. Silencing of CYP1B1 and AMPK with siRNA blocked the inhibitory effects of migration and invasion, and reversed the EMT related genes. | |
| PubChem ID | 161306 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:262125-1 | |
| Safety | Here, 2-hydroxy-6 -tridecylbenzoic acid inhibited MDA-MB-231 and 4 T-1 cells growth without toxicity to MCF-10A normal breast cells. |