| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-532 | |
| Phytochemical name or plant extracts | 2-Methylpyridine-1-ium-1-sulfonate | |
| PMID | 28624423 | |
| Literature evidence | In a concentration-dependent manner, the MPS was able to inhibit endothelial cell migration and angiogenesis in both in vivo and in vitro assays, and also significantly suppressed proliferation of MCF-7 and MDA-MB-231 human breast cancer cell lines. | |
| IUPAC name | 2-methylpyridin-1-ium-1-sulfonate | |
| Phytochemicals’ class or type of plant extracts | Sulfonate | |
| Source of phytochemicals or plant Extracts | Allium hirtifolium | |
| Geographical availability | Afghanistan, Iran, Iraq, Kazakhstan, Kirgizstan, Pakistan, Tadzhikistan, Turkey, Turkmenistan, Uzbekistan | |
| Plant parts | Bulb | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, Bcl-2, Caspase 3, Caspase 9, VEGF, MMP2, MMP9, p21, p27, p53 | |
| Gene or Protein evidence | Additionally, treatment with MPS showed a significant reduction in the vascular endothelial growth factor (VEGF) secretion level and production/activity of matrix metalloproteinases (MMP-2 and MMP-9) in the studied cells. Moreover, the compound-mediated apoptosis accompanied with the increase in the Bax/Bcl-2 ratio and caspase-3 and -9 activities. Our results indicated that the induction of cell cycle arrest was correlated with the obvious changes in expression of p21, p27 and p53. | |
| Target pathways | NA | |
| IC50 | 6.28 μM against MCF-7 7.93 μM against MDA-MB-231 | |
| Potency | In a concentration-dependent manner, the MPS was able to inhibit endothelial cell migration and angiogenesis in both in vivo and in vitro assays, and also significantly suppressed proliferation of MCF-7 and MDA-MB-231 human breast cancer cell lines. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | Finally, compounds with anticancer inhibitory activity (e.g. MPS) are abundant in nature and can be obtained from several sources. So, our data can be clinically developed for treating angiogenesis and cancer significantly. | |
| PubChem ID | 140652969 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:528159-1 | |
| Safety | NA |