Phytochemical Name : 2'-hydroxy-3',4',6'-trimethoxychalcone

Properties Information
PhytoCAT-ID PhytoCAT-1716
Phytochemical name or plant extracts 2'-hydroxy-3',4',6'-trimethoxychalcone
PMID 32433929
Literature evidence Flavonoid, stilbene and diarylheptanoid constituents of Persicaria maculosa Gray and cytotoxic activity of the isolated compounds.
IUPAC name (E)-3-(2-hydroxy-3,4,6-trimethoxyphenyl)-1-phenylprop-2-en-1-one
Phytochemicals’ class or type of plant extracts Chalcone
Source of phytochemicals or plant Extracts Persicaria maculosa
Geographical availability Afghanistan, Albania, Algeria, Altay, Amur, Austria, Azores, Baleares, Baltic States, Belarus, Belgium, Bulgaria, Central European Rus, China North-Central, China South-Central, China Southeast, Corse, Czechoslovakia, Denmark, East European Russia, East Himalaya, Egypt, Finland, France, Germany, Great Britain, Greece, Hungary, Inner Mongolia, Iran, Iraq, Ireland, Irkutsk, Italy, Japan, Kazakhstan, Kirgizstan, Korea, Krasnoyarsk, Krym, Laos, Lebanon-Syria, Madeira, Manchuria, Morocco, Nepal, Netherlands, North Caucasus, North European Russi, Northwest European R, Norway, Pakistan, Poland, Portugal, Qinghai, Romania, Sardegna, Saudi Arabia, Sicilia, South European Russi, Spain, Sweden, Switzerland, Tadzhikistan, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, Turkmenistan, Ukraine, Uzbekistan, Vietnam, West Himalaya, West Siberia, Xinjiang, Yemen, Yugoslavia
Plant parts Whole plants
Other cancers Breast cancer
Target gene or protein NA
Gene or Protein evidence NA
Target pathways NA
IC50 NA
Potency Impedance changes of 4 T1 mouse triple negative breast cancer cells treated with 2′-hydroxy-3′,4′,6′-trimethoxy chalcone (1) and pashanone (2) in concentrations of 10, 20 or 50 μmol/L.
Cell line/ mice model 4T1
Additional information  NA
PubChem ID 42607663
Additional PMIDs NA
Additional sources of information https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:695052-1
Safety NA