| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1270 | |
| Phytochemical name or plant extracts | 2'-Hydroxyflavanone | |
| PMID | 30136444 | |
| Literature evidence | Therefore, our results indicate that 2HF may suppress BC growth in vitro and in vivo by targeting RLIP76, and may serve as a potential adjuvant treatment in BC patients. © 2018 Wiley Periodicals, Inc. | |
| IUPAC name | 2-(2-hydroxyphenyl)-2,3-dihydrochromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Citrus sinensis | |
| Geographical availability | Possibly Asia in southern China and Vietnam. | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer, Kidney cancer, Lung cancer, Bladder cancer, Colon cancer, Prostate cancer | |
| Target gene or protein | Ki67, CD31, Vimentin, Survivin, Bcl-2, Bax, E-cadherin, PARP, RLIP76 | |
| Gene or Protein evidence | Furthermore, 2HF decreased expression of Ki67, CD31, vimentin, inhibited phosphorylation of Akt and expression of survivin and Bcl2, and increased levels of Bax, E-cadherin, and cleaved-PARP. Therefore, our results indicate that 2HF may suppress BC growth in vitro and in vivo by targeting RLIP76, and may serve as a potential adjuvant treatment in BC patients. | |
| Target pathways | RLIP76 has been shown to regulate PI3 K/Akt signaling pathway, aberrant activation of which plays a role in increased cell proliferation, 2HF strongly inhibited the ER and HER2 networks in MCF7 and SKBR3 cells along with inhibiting IGF1 and macropinocytosis canonical pathways in MDA-MB231 cells. | |
| IC50 | 27+/-3 µM against MCF-7 23+/-2 µM against SKBR-3 32+/-4 µM against MDA-MB-231 30+/-3 µM against T47D | |
| Potency | Therefore, our results indicate that 2HF may suppress BC growth in vitro and in vivo by targeting RLIP76, and may serve as a potential adjuvant treatment in BC patients. | |
| Cell line/ mice model | MCF-7 or SKBR-3 BC cells, MDA-MB-231, TMD231, MCF10a and T47D cells. | |
| Additional information | 2HF induced significant changes in the proteins responsible for BC incidence, metastases and therapeutic sensitivity in BC cells. | |
| PubChem ID | 176925 | |
| Additional PMIDs | 30248461 29088842 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:772052-1 | |
| Safety | NA |