| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1948 | |
| Phytochemical name or plant extracts | 2'-Hydroxycinnamaldehyde | |
| PMID | 23283523 | |
| Literature evidence | This study demonstrates the anti-metastatic effect of the non-toxic natural compound HCA through attenuation of EMT in a breast cancer model. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | (E)-3-(2-hydroxyphenyl)prop-2-enal | |
| Source of phytochemicals or plant Extracts | Cinnamomum cassia Blume | |
| Geographical availability | Bangladesh, Borneo, China South-Central, China Southeast, Hainan, Jawa, Lesser Sunda Is., Myanmar, Philippines, Sulawesi, Sumatera, Taiwan, Vietnam | |
| Plant parts | Bark | |
| Other cancers | Breast cancer | |
| Target gene or protein | E-cadherin, KLF17, Id-1, EMT | |
| Gene or Protein evidence | HCA induces epithelial reversion at nanomolar concentrations by suppressing Snail via the nuclear translocalization of GSK-3β, which results in the transcriptional upregulation of E-cadherin. HCA also activates the transcription factor KLF17, which suppresses Id-1, indicating that HCA inhibits EMT by multiple transcriptional programs. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MCF-7, T47D, MDA-MB-231, MDA-MB-435, mice model | |
| Additional information | Further, HCA treatment significantly inhibits lung metastasis in a mouse orthotopic breast cancer model. This study demonstrates the anti-metastatic effect of the non-toxic natural compound HCA through attenuation of EMT in a breast cancer model. | |
| PubChem ID | 5318169 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:463347-1 | |
| Safety | NA |