| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-759 | |
| Phytochemical name or plant extracts | 2',4'-dihydroxy-3'-(2-hydroxybenzyl)-6'-methoxychalcone | |
| PMID | 16833018 | |
| Literature evidence | A new natural C-benzylated chalcone, 2',4'-dihydroxy-3'-(2-hydroxybenzyl)-6'-methoxychalcone (2), along with two other flavonoids, tiliroside and kaempferol 3-O-rutinoside, and an oxoaporphine alkaloid, lanuginosine were isolated from the aerial parts of Ellipeiopsis cherrevensis (Annonaceae). | |
| IUPAC name | 1-[2,4-dihydroxy-3-[(2-hydroxyphenyl)methyl]-6-methoxyphenyl]-3-phenylprop-2-en-1-one | |
| Phytochemicals’ class or type of plant extracts | Chalcone | |
| Source of phytochemicals or plant Extracts | Ellipeiopsis cherrevensis | |
| Geographical availability | Cambodia, Thailand | |
| Plant parts | Aerial parts | |
| Other cancers | Breast cancer, Lung cancer, Epidermoid cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 13.92 μg/mL against BC | |
| Potency | The chalcone 2 exhibited cytotoxic activity against human small-cell lung-cancer (NCI-H187), epidermoid carcinoma (KB) and breast cancer (BC) cell lines with IC50 values of 1.40, 5.31 and 13.92 microg/mL, respectively. | |
| Cell line/ mice model | BC, NCI-H187, KB | |
| Additional information | This compound also showed antimalarial activity against Plasmodium falciparum with an IC50 value of 7.1 microg/mL as well as antimicrobacterial activity against Mycobacterium tuberculosis with a MIC of 25 mg/mL. | |
| PubChem ID | 74493747 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:72938-1 | |
| Safety | NA |