| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-590 | |
| Phytochemical name or plant extracts | 17-ethylene-3,4-dihydroxy-5-pregnene-16-one | |
| PMID | 34181358 | |
| Literature evidence | The execution of apoptosis may be related to the increase of the ratio of BAX/bcl-2 of the cells. Conclusion: The EtOAc fraction of Melia azedarach L. leaves and the isolated 5-pregnene-16-one steroids are promising reagents for breast cancer treatment by introducing apoptosis to tumor cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Steroid | |
| Source of phytochemicals or plant Extracts | Melia azedarach. | |
| Geographical availability | Assam, Bangladesh, Cambodia, China North-Central, China South-Central, China Southeast, East Himalaya, Hainan, India, Jawa, Laos, Lesser Sunda Is., Nepal, New Guinea, New South Wales, Northern Territory, Philippines, Queensland, Solomon Is., Sri Lanka, Sumatera, Taiwan, Thailand, Vietnam, West Himalaya, Western Australia | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, Bcl-2 | |
| Gene or Protein evidence | The execution of apoptosis may be related to the increase of the ratio of BAX/bcl-2 of the cells. | |
| Target pathways | NA | |
| IC50 | 62.2 µg/mL against T47D | |
| Potency | These compounds showed moderate cytotoxicity (IC50 172.9 and 62.2 µg/mL, respectively) comparable to doxorubicin (IC50 3.08 µg/mL). | |
| Cell line/ mice model | T47D | |
| Additional information | The EtOAc fraction of Melia azedarach L. leaves and the isolated 5-pregnene-16-one steroids are promising reagents for breast cancer treatment by introducing apoptosis to tumor cells. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:578949-1 | |
| Safety | NA |