| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-406 | |
| Phytochemical name or plant extracts | 15,16-Dihydrotanshinone I | |
| PMID | 21274285 | |
| Literature evidence | Results suggest that DHTS can induce apoptosis of prostate carcinoma cells via induction of ER stress and/or inhibition of proteasome activity, and may have therapeutic potential for prostate cancer patients. | |
| IUPAC name | (1R)-1,6-dimethyl-1,2-dihydronaphtho[1,2-g][1]benzofuran-10,11-dione | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Salvia miltiorrhiza | |
| Geographical availability | China North-Central, China South-Central, China Southeast, Vietnam | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | ERp57 | |
| Gene or Protein evidence | DHT potentially inhibited ERp57 activity and suppressed ERp57 expression at both the RNA and protein levels. | |
| Target pathways | UPR pathway | |
| IC50 | NA | |
| Potency | In conclusion, our data implied that DHT targeted ERp57 for inhibition and induced ER stress and UPR activation, which in turn triggered breast cancer cell apoptosis. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | DHTS was able to induce ER stress as evidenced by the upregulation of glucose regulation protein 78 (GRP78/Bip) and CAAT/enhancer binding protein homologous protein/growth arrest- and DNA damage-inducible gene 153 (CHOP/GADD153), as well as increases in phosphorylated eukaryotic initiation factor 2α (eIF2α), c-jun N-terminal kinase (JNK), and X-box-binding protein 1 (XBP1) mRNA splicing forms. | |
| PubChem ID | 11425923 | |
| Additional PMIDs | 31316608 34062127 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:456707-1 | |
| Safety | NA |