| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-391 | |
| Phytochemical name or plant extracts | 14-Deoxy-11,12-didehydroandrographolide | |
| PMID | 27049118 | |
| Literature evidence | In this study, the mechanistic toxicology properties of 14-DDA in T-47D cells were further investigated. 14-DDA is found to induce the formation of endoplasmic reticulum (ER) vacuoles and autophagosomes, with concurrent upregulation of LC3-II in the breast carcinoma cells. | |
| IUPAC name | 4-[(E)-2-[(1R,4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethenyl]-2H-furan-5-one | |
| Phytochemicals’ class or type of plant extracts | Terpenoid | |
| Source of phytochemicals or plant Extracts | Andrographis paniculata | |
| Geographical availability | Assam, Bangladesh, India, Nepal, Sri Lanka, West Himalaya | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | GADD45A/p38 MAPK/DDIT3 | |
| Gene or Protein evidence | Collectively, it is possible that GADD45A/p38 MAPK/DDIT3 pathway is involved in the 14-DDA-induced ER-stress-mediated autophagy in T-47D cells. | |
| Target pathways | GADD45A/p38 MAPK/DDIT3 pathway | |
| IC50 | NA | |
| Potency | DDIT3 knockdown suppressed the formation of both ER vacuoles and autophagosomes, indicating that 14-DDA-induced ER stress and autophagy is dependent on this transcription factor. | |
| Cell line/ mice model | T-47D | |
| Additional information | 14-DDA is found to induce the formation of endoplasmic reticulum (ER) vacuoles and autophagosomes, with concurrent upregulation of LC3-II in the breast carcinoma cells. It stimulated an increase in cytosolic calcium concentration and caused a collapse in mitochondrial membrane potential in these cells. In addition, both DDIT3 and GADD45A, molecules implicated in ER stress pathway, were significantly upregulated. | |
| PubChem ID | 5708351 | |
| Additional PMIDs | 22101062 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:45226-1 | |
| Safety | NA |