| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-758 | |
| Phytochemical name or plant extracts | 13-methoxy-15-oxozoapatlin | |
| PMID | 8620568 | |
| Literature evidence | Two structurally novel cytotoxic ent-kaurene diterpenoids, 13-methoxy-15-oxozoapatlin and 13-hydroxy-15-oxozoapatlin, were isolated from the root bark of Parinari curatellifolia, together with the known compound, 15-oxozoapatlin, on the basis of bioactivity-guided chromatographic fractionation and found to demonstrate broad-spectrum cytotoxic activity against a panel of cultured human cancer cell lines. | |
| IUPAC name | (1R,2S,5S,8R,11R,12R)-5-methoxy-12-methyl-6-methylidene-16-oxapentacyclo[10.3.2.15,8.01,11.02,8]octadecane-7,17-dione | |
| Phytochemicals’ class or type of plant extracts | Ent-kaurene Diterpenoid | |
| Source of phytochemicals or plant Extracts | Parinari curatellifolia | |
| Geographical availability | Angola, Benin, Burkina, Burundi, Cameroon, Caprivi Strip, Central African Repu, Chad, Congo, Gambia, Ghana, Guinea, Guinea-Bissau, Kenya, Madagascar, Malawi, Mali, Mozambique, Namibia, Niger, Nigeria, Northern Provinces, Rwanda, Senegal, Sierra Leone, Sudan, Tanzania, Togo, Uganda, Zambia, Zaïre, Zimbabwe | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | No antitumor activity was observed when athymic mice carrying KB cells were treated with 13-methoxy-15-oxozoapatlin. These data indicate that the cytotoxic activity of 13-methoxy-15-oxozoapatlin is mediated in part by covalent reaction with a cellular component (such as sulfhydryl-containing protein) by means of a Michael-type addition, and this results in the blockage of cell-cycle progression. | |
| Cell line/ mice model | ZR-75-1, Athymic mice carrying KB cells | |
| Additional information | These data indicate that the cytotoxic activity of 13-methoxy-15-oxozoapatlin is mediated in part by covalent reaction with a cellular component (such as sulfhydryl-containing protein) by means of a Michael-type addition, and this results in the blockage of cell-cycle progression. | |
| PubChem ID | 102374019 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:727095-1 | |
| Safety | NA |