| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-125 | |
| Phytochemical name or plant extracts | 13-O-acetylsolstitialin A | |
| PMID | 31161672 | |
| Literature evidence | Centaurea cyanus extracted 13-O-acetylsolstitialin A decrease Bax/Bcl-2 ratio and expression of cyclin D1/Cdk-4 to induce apoptosis and cell cycle arrest in MCF-7 and MDA-MB-231 breast cancer cell lines. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Sesquiterpene lactone | |
| Source of phytochemicals or plant Extracts | Centaurea cyanus | |
| Geographical availability | Albania, Bulgaria, East Aegean Is., Greece, Italy, Lebanon-Syria, Romania, Sicilia, Turkey, Turkey-in-Europe, Yugoslavia | |
| Plant parts | Aerial parts | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, Bcl-2, Cyclin D1, CDK-4 | |
| Gene or Protein evidence | in both cell lines, 13ASA decreased protein levels of cyclin D1 and Cdk-4 in a dose-dependent manner. Altogether, these results indicate 13ASA induces cell cycle arrest probably through downregulation of cyclin D1 and Cdk-4 protein levels. | |
| Target pathways | NA | |
| IC50 | 71.27 ± 4.3 µM against MCF-7 67.08 ± 3.6 µM against MDA-MB-231 | |
| Potency | NA | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | ROS overproduction after 13ASA treatment possibly is one of the triggers for apoptosis. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:190310-1 | |
| Safety | NA |