| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1912 | |
| Phytochemical name or plant extracts | 10-hydroxy camptothecin | |
| PMID | 28822757 | |
| Literature evidence | Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin. | |
| IUPAC name | (19S)-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione | |
| Phytochemicals’ class or type of plant extracts | Pyranoindolizinoquinoline. | |
| Source of phytochemicals or plant Extracts | Nothapodytes nimmoniana | |
| Geographical availability | Assam, Cambodia, East Himalaya, India, Myanmar, Nansei-shoto, Philippines, Sri Lanka, Sumatera, Taiwan, Thailand, Vietnam | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Liver cancer | |
| Target gene or protein | p21 | |
| Gene or Protein evidence | Compared to the treatment by Qu or HCPT alone, phosphorylation at Ser139 of γH2A.X in MCF7 cells starts to increase significantly (P<0.05) at 6h when treated by the combination of 10μM Qu and 0.62μM HCPT. Moreover, the combinational group successively arrests MCF7 cells at G1, S and G2/M phases from 12h to 48h via up-regulation of p21 and induces apoptosis at 24h by triggering intrinsic cell death pathways. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MCF-7, BGC823 and HepG2 | |
| Additional information | In summary, the synergic anti-cancer mechanism of Qu and HCPT in MCF7 cells is through the combined inhibitory effects of Qu and HCPT on Topo I, which synergistically induce cell cycle arrest and apoptosis by triggering DNA damage. | |
| PubChem ID | 97226 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:77183920-1 | |
| Safety | NA |