| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1632 | |
| Phytochemical name or plant extracts | 1-naphthyl isothiocyanate | |
| PMID | 15337839 | |
| Literature evidence | BITC and PEITC can inhibit the growth of human breast cancer cells as well as human mammary epithelium cells at concentrations similar to those of the chemotherapeutic drug DNM. | |
| IUPAC name | 1-isothiocyanatonaphthalene | |
| Phytochemicals’ class or type of plant extracts | Isothiocyanate | |
| Source of phytochemicals or plant Extracts | Cruciferous vegetables | |
| Geographical availability | NA | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 77.9 ± 8.03 μM against MCF-7/Adr for 48 hours 89.2 ± 10.8 μM against MCF-7/wt for 3 hours 78.4 ± 5.26 μM against MCF-7/wt for 48 hours | |
| Potency | Sulforaphane and NITC exhibited higher IC50 values. | |
| Cell line/ mice model | MCF-7/Adr, MCF-7/wt | |
| Additional information | The effect of these ITCs on cell growth may contribute to the cancer chemopreventive properties of ITCs by suppressing the growth of preclinical tumors, and may indicate a potential use of these compounds as chemotherapeutic agents in cancer treatment. | |
| PubChem ID | 11080 | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |