| Properties | Information |
|---|---|
| PhytoCAT-ID | PhytoCAT-1763 |
| Phytochemical name or plant extracts | 1-benzyl-I3C |
| PMID | 22012859 |
| Literature evidence | Expression of the wild type and Δ205 elastase in MDA-MB-231 human breast cancer cells demonstrated that the carboxyterminal domain of elastase is required for the I3C and 1-benzyl-I3C inhibition of enzymatic activity, accumulation of the unprocessed form of the CD40 elastase substrate (a tumor necrosis factor receptor family member), disruption of NFκB nuclear localization and transcriptional activity, and induction of a G1 cell cycle arrest. |
| IUPAC name | (1-benzylindol-3-yl)methanol |
| Phytochemicals’ class or type of plant extracts | NA |
| Source of phytochemicals or plant Extracts | NA |
| Geographical availability | NA |
| Plant parts | NA |
| Other cancers | Breast cancer |
| Target gene or protein | CD40, CDK6 |
| Gene or Protein evidence | Expression of the wild type and Δ205 elastase in MDA-MB-231 human breast cancer cells demonstrated that the carboxyterminal domain of elastase is required for the I3C and 1-benzyl-I3C inhibition of enzymatic activity, accumulation of the unprocessed form of the CD40 elastase substrate (a tumor necrosis factor receptor family member), disruption of NFκB nuclear localization and transcriptional activity, and induction of a G1 cell cycle arrest. At significantly lower concentrations, 1-benzyl-I3C induced a robust G1 cell cycle arrest and elicited the key I3C-specific effects on expression and activity of G1-acting cell cycle genes including the disruption of endogenous interactions of the Sp1 transcription factor with the CDK6 promoter. |
| Target pathways | NA |
| IC50 | NA |
| Potency | Our results implicate 1-benzyl-I3C as a novel, potent inhibitor of human breast cancer proliferation and estrogen responsiveness that could potentially be developed into a promising therapeutic agent for the treatment of indole-sensitive cancers. |
| Cell line/ mice model | MCF-7, MDA-MB-231 |
| Additional information | NA |
| PubChem ID | 402633 |
| Additional PMIDs | 20570586 22012859 |
| Additional sources of information | NA |
| Safety | NA |