| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-927 | |
| Phytochemical name or plant extracts | 1-O-trans-p-coumaroyl-2-O-trans-caffeoyl-α-L-rhamnopyranose | |
| PMID | 28809058 | |
| Literature evidence | Acylated rhamnopyranoses are potential novel c-Met inhibitors appropriate for future optimizations to control c-Met-dependent breast malignancies. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Glycoside | |
| Source of phytochemicals or plant Extracts | Premna odorata | |
| Geographical availability | Assam, Bangladesh, Bismarck Archipelago, Borneo, Cambodia, Christmas I., Hainan, India, Jawa, Laos, Lesser Sunda Is., Malaya, Maluku, Myanmar, New Guinea, Northern Territory, Philippines, Queensland, Sri Lanka, Sulawesi, Sumatera, Taiwan, Thailand, Vietnam | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | c-met | |
| Gene or Protein evidence | Acylated rhamnopyranoses are potential novel c-Met inhibitors appropriate for future optimizations to control c-Met-dependent breast malignancies. | |
| Target pathways | NA | |
| IC50 | The MTT cell proliferation assay testing against the human c-Met-expressing highly invasive MDA-MB-23 suggested compound 9 as the most active with IC50 value of 13.3 µM. | |
| Potency | Cell-free Z'-LYTE™ assay testing revealed the good c-Met phosphorylation inhibitory activity of 9, followed by 8, and 10, with IC50 values of 2.5, 6.9, and 12.7 μM, respectively. | |
| Cell line/ mice model | MCF-7, BT-474 cells, and MDA-MB-468 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:864355-1 | |
| Safety | NA |