| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1079 | |
| Phytochemical name or plant extracts | 1-(4-hydroxy-2-methoxybenzofuran-5-yl)-3-phenylpropane-1,3-dione | |
| PMID | 27034599 | |
| Literature evidence | OBJECTIVE: To isolate and characterize bioactive compounds of aerial parts of C. argentea and evaluate their anticancer potential. | |
| IUPAC name | 1-(4-hydroxy-2-methoxybenzofuran-5-yl)-3-phenylpropane-1,3-dione | |
| Phytochemicals’ class or type of plant extracts | Phenolic compound | |
| Source of phytochemicals or plant Extracts | Celosia argentea | |
| Geographical availability | Benin, Cameroon, Central African Repu, Chad, Congo, Equatorial Guinea, Eritrea, Ethiopia, Gabon, Ghana, Guinea, Guinea-Bissau, Ivory Coast, Kenya, Liberia, Malawi, Niger, Nigeria, Senegal, Sierra Leone, Somalia, Sudan, Tanzania, Uganda, Zambia, Zaïre | |
| Plant parts | Aerial parts | |
| Other cancers | Breast cancer, Colorectal cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | Antioxidant potential- 21.30 μg/ml | |
| Potency | Compound 1 and 2 showed potent cytotoxicity against SiHa, HCT, MCF-7 cancer cell lines at 20 μg/ml (****P < 0.0001) and 18 μg/ml (**P < 0.01), respectively, without affecting the normal Vero cells. Compound 2 is 1-(4-hydroxy-2-methoxybenzofuran-5-yl)-3-phenylpropane-1,3-dione | |
| Cell line/ mice model | MCF-7, SiHa, HCT | |
| Additional information | A novel anticancer phenolic compound, (1-(4-hydroxy-2-methoxybenzofuran-5-yl)-3-phenylpropane-1,3-dione), isolated from aerial parts of C. argentea was a valuable finding of the research. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:316350-2 | |
| Safety | NA |