| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-767 | |
| Phytochemical name or plant extracts | 1-(2-hydroxyphenyl)-4-methylpentan-1-one | |
| PMID | 31281587 | |
| Literature evidence | Cytochrome c release from mitochondria and changes in mitochondrial membrane potential of treated cells supported the intrinsic apoptotic cell death. | |
| IUPAC name | 1-(2-hydroxyphenyl)-4-methylpentan-1-one | |
| Phytochemicals’ class or type of plant extracts | Ketone | |
| Source of phytochemicals or plant Extracts | Rubus fairholmianus | |
| Geographical availability | India, Sri Lanka | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer | |
| Target gene or protein | PARP | |
| Gene or Protein evidence | PARP cleavage and higher expression of cleaved PARP in the C1- and C2-treated groups and the generation of intracellular ROS assured the induction of apoptosis. | |
| Target pathways | Rubus species (C1 and C2) induce apoptosis in human breast cancer cells by causing accumulation of intracellular ROS, by activation of mitochondrial signaling pathway by showing higher expression of cleaved PARP, caspase 9, cytochrome c, and Bax apoptotic proteins | |
| IC50 | 4.69 μg/mL against MCF-7 | |
| Potency | These results illustrate that berry bioactive compounds have strong chemopreventive potential. In this article, we provide information on prooxidant and anticancer activities of Rubus bioactive compounds. Natural products have always demonstrated a significant contribution to the development of several cancer chemotherapeutic drugs. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | NA | |
| PubChem ID | 122392324 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:736704-1 | |
| Safety | NA |