| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1981 | |
| Phytochemical name or plant extracts | 1,3,6-Trihydroxy-7-methyl-9,10-anthracenedione | |
| PMID | 27291048 | |
| Literature evidence | OBJECTIVE: To investigate the chemical constituents of the root tubers of Lindera aggregate and the stems of Linderanacusua, and to find natural inhibitors on the expression level on fatty acid synthase in human breast cancer MDA-MB-231 cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Quinone | |
| Source of phytochemicals or plant Extracts | Lindera | |
| Geographical availability | Alabama, Arkansas, Connecticut, Delaware, District of Columbia, Florida, Georgia, Illinois, Indiana, Kansas, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Mississippi, Missouri, New Hampshire, New Jersey, New York, North Carolina, Ohio, Oklahoma, Ontario, Pennsylvania, Rhode I., South Carolina, Tennessee, Texas, Vermont, Virginia, West Virginia | |
| Plant parts | Root tubers | |
| Other cancers | Breast cancer | |
| Target gene or protein | Fatty acid synthase | |
| Gene or Protein evidence | Among them, 1,3,6-Trihydroxy-7-methyl-9,10-anthracenedione (TMA, compound 6) showed strong inhibitory effect on the expression level on fatty acid synthase in human breast cancer MDA-MB-231 cells. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | In addition, TMA was found to reduce breast cancer cells viability dosedependently. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:140503-2 | |
| Safety | NA |