| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1896 | |
| Phytochemical name or plant extracts | 1, 3, 7, 8-tetrahydroxyxanthone | |
| PMID | 28411691 | |
| Literature evidence | Compounds 1-6, 9-11, and 14-17 were tested for their cytotoxicity against human breast-cancer T47D, MCF-7 and MDA-MB-231 cells in vitro, and compounds 2, 5, 6, 10 and 11 showed significant cytotoxicity (IC50 values < 10 μmol·L-1) against T47D cells. | |
| IUPAC name | 1,2,6,8-tetrahydroxyxanthen-9-one | |
| Phytochemicals’ class or type of plant extracts | Xanthone | |
| Source of phytochemicals or plant Extracts | Sinopodophyllum hexandrum | |
| Geographical availability | Afghanistan, China North-Central, China South-Central, East Himalaya, Nepal, Pakistan, Qinghai, Tibet, West Himalaya | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 9.4 ± 2.0 μmol/L against T47D > 100 μmol/L against MDA-MB-231 | |
| Potency | compounds 2, 5, 6, 10 and 11 showed significant cytotoxicity (IC50 values < 10 μmol·L-1) against T47D cells. Compound 11 is 1, 3, 7, 8-tetrahydroxyxanthone | |
| Cell line/ mice model | T47D, MCF-7, MDA-MB-231 | |
| Additional information | NA | |
| PubChem ID | 5281658 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:77137821-1 | |
| Safety | NA |