| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-828 | |
| Phytochemical name or plant extracts | 1'S-1'-acetoxyeugenol acetate | |
| PMID | 20729047 | |
| Literature evidence | AEA was also found to induce cell cycle arrest in MCF-7 cells at the G(0)/G(1) phase with no adverse cell cycle arrest effects on HMEC normal control cells. | |
| IUPAC name | [4-(1-acetyloxyprop-2-enyl)-2-methoxyphenyl] acetate | |
| Phytochemicals’ class or type of plant extracts | Phenylpropanoid | |
| Source of phytochemicals or plant Extracts | Alpinia conchigera | |
| Geographical availability | Andaman Is., Bangladesh, Cambodia, Malaya, Myanmar, Philippines, Sumatera, Thailand, Vietnam | |
| Plant parts | Rhizome | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | Nuclear factor-kappaB (NF-κB) pathway | |
| IC50 | 14.0 μM against MCF-7 at 36h 8 μM/ml against MCF-7 at 24h 3.4 μM/ml against MCF-7 at 48h | |
| Potency | Therefore, it was concluded that AEA isolated from the Malaysian tropical ginger (A. conchigera) served as a very promising candidate for further in-vivo development in animal models and in subsequent clinical trials involving patients with breast-related malignancies. | |
| Cell line/ mice model | MCF-7, HMEC | |
| Additional information | AEA was also found to induce cell cycle arrest in MCF-7 cells at the G(0)/G(1) phase with no adverse cell cycle arrest effects on HMEC normal control cells. Consequent to this, western blot analysis of proteins corresponding to the NF-κB pathway indicated that AEA inhibited phosphorylation levels of the inhibitor of κB-kinase complex, resulting in the elimination of apoptotic resistance originating from NF-κB activation. | |
| PubChem ID | 4484222 | |
| Additional PMIDs | 21346553 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:795246-1 | |
| Safety | NA |