| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2 | |
| Phytochemical name or plant extracts | 1'-acetoxychavicol acetate | |
| PMID | 25301089 | |
| Literature evidence | The chavicol preferentially suppressed cancer cell migration and invasion, and this activity was superior to its cytotoxic effects. | |
| IUPAC name | [4-[(1S)-1-acetyloxyprop-2-enyl]phenyl] acetate | |
| Phytochemicals’ class or type of plant extracts | Acetate ester | |
| Source of phytochemicals or plant Extracts | Alpinia galanga | |
| Geographical availability | Assam, Bangladesh, Borneo, Cambodia, China South-Central, China Southeast, Hainan, Jawa, Malaya, Myanmar, Philippines, Sumatera, Thailand, Vietnam | |
| Plant parts | Rhizome | |
| Other cancers | Breast cancer | |
| Target gene or protein | STAT-3, MMP2, MMP9 | |
| Gene or Protein evidence | ACA suppressed both constitutive and interleukin-6-inducible STAT3 activation and diminished the accumulation of STAT3 in the nucleus and its DNA-binding activity. Matrix metalloproteinase (MMP)-2 and -9, gene products of STAT3 that regulate cell invasion, were specifically suppressed by ACA. | |
| Target pathways | SHP-1/STAT3/MMPs signaling pathway | |
| IC50 | 23.9 µM against MCF-7 | |
| Potency | The Malaysian Alpinia galanga showed weak activity compared with the Thai sample and this was shown to be due to the relatively high amounts of 1'-acetoxychavicol acetate present in the Thai sample. | |
| Cell line/ mice model | MCF-7, COR L23 | |
| Additional information | This study aimed to evaluate the mode of anticancer effects of 1'-acetoxychavicol acetate, which is isolated from the rhizomes of Alpinia galanga in estrogen receptor positive (MCF7) human epidermal growth factor receptor 2-overexpressed (MCF7/HER2), and endocrine-resistant breast cancer cells (MCF7/LCC2 and MCF7/LCC9). 1'-Acetoxychavicol acetate showed antiproliferation in a concentration- and time-dependent fashion and had higher potency in human epidermal growth factor receptor 2-overexpressed cell lines. mall molecule 1'-acetoxychavicol acetate suppresses breast tumor metastasis by regulating the SHP-1/STAT3/MMPs signaling pathway. The purpose of this study is to investigate whether the natural agent 1'-acetoxychavicol acetate (ACA), derived from the rhizomes and seeds of Languas galanga, could suppress breast cancer metastasis by targeting STAT3 signaling pathway. | |
| PubChem ID | 119104 | |
| Additional PMIDs | 15888378 33445186 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:872737-1 | |
| Safety | NA |