| Properties | Information |
|---|---|
| PhytoCAT-ID | PhytoCAT-1903 |
| Phytochemical name or plant extracts | ω-Hydroxyundec-9-enoic acid (ω-HUA) |
| PMID | 28681938 |
| Literature evidence | However, its effect on breast cancer cells is unknown. Here, we investigated the anti- breast cancer activity of ω-HUA and its underlying mechanism. |
| IUPAC name | (E)-11-hydroxyundec-9-enoic acid |
| Phytochemicals’ class or type of plant extracts | Fatty acid |
| Source of phytochemicals or plant Extracts | NA |
| Geographical availability | NA |
| Plant parts | NA |
| Other cancers | Breast cancer |
| Target gene or protein | p38 |
| Gene or Protein evidence | Treatment of human breast cancer cell lines, MDA-MB-231 and MDA-MB-435, with ω-HUA induced apoptotic cell death with increased cleaved caspase-3 and poly (ADP-ribose) polymerase (PARP) levels, and p38 and JNK phosphorylation. |
| Target pathways | Collectively, ω-HUA-induced intracellular ROS generation induced breast cancer cell apoptosis through JNK and p38 signaling pathway activation, resulting in tumor regression. |
| IC50 | NA |
| Potency | The results suggested that ω-HUA is an effective supplement for inhibiting human breast cancer growth. |
| Cell line/ mice model | MDA-MB-231, MDA-MB-435 |
| Additional information | ω-Hydroxyundec-9-enoic acid (ω-HUA), a plant secondary metabolite, exhibits anti-fungal activity. |
| PubChem ID | 12780978 |
| Additional PMIDs | NA |
| Additional sources of information | NA |
| Safety | NA |