| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1059 | |
| Phytochemical name or plant extracts | γ-Tocotrienol | |
| PMID | 23266736 | |
| Literature evidence | Results showed that treatment with γ-tocotrienol or sesamin alone induced a significant dose-responsive growth inhibition, whereas combination treatment with these agents synergistically inhibited the growth of +SA, MCF-7 and MDA-MB-231 mammary cancer cells, while similar treatment doses were found to have little or no effect on normal (mouse CL-S1 and human MCF-10A) mammary epithelial cell growth or viability. | |
| IUPAC name | (2R)-2,7,8-trimethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl]-3,4-dihydrochromen-6-ol | |
| Phytochemicals’ class or type of plant extracts | Tocotrienol | |
| Source of phytochemicals or plant Extracts | Amaranthus cruentus | |
| Geographical availability | El Salvador, Guatemala, Honduras, Mexico Central, Mexico Gulf, Mexico Southeast, Mexico Southwest, Nicaragua | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Cyclin D1, CDK2, CDK4, CDK6, Rb, E2F1, p27, p16 | |
| Gene or Protein evidence | Rather, combined treatment with subeffective doses of γ-tocotrienol and sesamin was found to induce G1 cell cycle arrest, and a corresponding decrease in cyclin D1, CDK2, CDK4, CDK6, phospho-Rb, and E2F1 levels, and increase in p27 and p16 levels. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Taken together, these findings indicate that the synergistic antiproliferative action of combined γ-tocotrienol and sesamin treatment in mouse and human mammary cancer cells is cytostatic, not cytotoxic, and results from G1 cell cycle arrest. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | 1) Thus, these data suggest that gamma-tocotrienol protects against oxidative stress-induced cellular ageing by modulating the telomere length possibly via telomerase. 2)Overall, our results demonstrate that gamma-tocotrienol inhibited the NF-kappaB activation pathway, leading to down-regulation of various gene products and potentiation of apoptosis. | |
| PubChem ID | 5282349 | |
| Additional PMIDs | 17704032 17114179 20716926 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:10631-2 | |
| Safety | NA |