| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-525 | |
| Phytochemical name or plant extracts | β-sitosterol | |
| PMID | 29411647 | |
| Literature evidence | In addition, compounds 1, 2, 3, and 4 showed promising cytotoxic effect on MCF-7 cells with IC50 values of 21.03, 15.42, 10.089, and 11.34 μg/mL, respectively. | |
| IUPAC name | (3S,8S,9S,10R,13R,14S,17R)-17-[(2R,5R)-5-ethyl-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol | |
| Phytochemicals’ class or type of plant extracts | Phytosterol | |
| Source of phytochemicals or plant Extracts | Vicia monantha | |
| Geographical availability | Afghanistan, Algeria, Baleares, Canary Is., Cyprus, East Aegean Is., Egypt, Greece, Gulf States, India, Iran, Iraq, Italy, Kirgizstan, Lebanon-Syria, Libya, Morocco, North Caucasus, Oman, Pakistan, Palestine, Sardegna, Saudi Arabia, Sicilia, Sinai, Spain, Tadzhikistan, Transcaucasus, Tunisia, Turkey, Turkmenistan, Uzbekistan, West Himalaya | |
| Plant parts | Seeds | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 15.42 μg/mL against MCF-7 | |
| Potency | In addition, compounds 1, 2, 3, and 4 showed promising cytotoxic effect on MCF-7 cells with IC50 values of 21.03, 15.42, 10.089, and 11.34 μg/mL, respectively. | |
| Cell line/ mice model | MCF-7, HCT-116, HepG2 | |
| Additional information | Only compounds 1, 2, and 4 showed cytotoxic effect on HCT-116 cells where compound 2 was the most active with IC50 value of 22.61 μg/mL. Compound 2 is β-sitosterol. | |
| PubChem ID | 222284 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:524947-1 | |
| Safety | NA |