| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-353 | |
| Phytochemical name or plant extracts | α-mangostin | |
| PMID | 31343173 | |
| Literature evidence | Microtubule affinity regulating kinase 4 (MARK4) is a potential drug target for neuronal disorders and several types of cancers. | |
| IUPAC name | 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one | |
| Phytochemicals’ class or type of plant extracts | Xanthone | |
| Source of phytochemicals or plant Extracts | Garcinia mangostana | |
| Geographical availability | Borneo, Malaya | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Liver cancer | |
| Target gene or protein | MMP2, MMP9, MARK4 | |
| Gene or Protein evidence | alpha-Mangostin, a novel dietary xanthone, suppresses TPA-mediated MMP-2 and MMP-9 expressions through the ERK signaling pathway in MCF-7 human breast adenocarcinoma cells. Enzyme inhibition and binding studies showed that α-mangostin inhibited MARK4 in the submicromolar range with IC50 = 1.47 μM and binding constant (Ka) 5.2 × 107 M-1. | |
| Target pathways | ERK signaling | |
| IC50 | 9.95 ± 0.45 μM against MCF7- | |
| Potency | Studies on anticancer/apoptotic potential of α-mangostin showed that it inhibits the growth of cancerous cells. | |
| Cell line/ mice model | MCF-7, HepG2 | |
| Additional information | It was found that the oxygen atom of two hydroxyl groups of α-mangostin interacts with Lys64, Lys85, and Asp196 via hydrogen bonding, and these residues belong to the catalytic domain of MARK4. | |
| PubChem ID | 5281650 | |
| Additional PMIDs | 20492173 24480042 22577295 32154152 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:428073-1 | |
| Safety | acute toxic in pubmed database |