| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-878 | |
| Phytochemical name or plant extracts | α-conidendrin | |
| PMID | 31971313 | |
| Literature evidence | These results suggest that α-conidendrin can be a promising agent for treatment of breast cancer with little or no toxicity against normal cells. © 2020 John Wiley & Sons, Ltd. | |
| IUPAC name | (3aR,9S,9aR)-7-hydroxy-9-(4-hydroxy-3-methoxyphenyl)-6-methoxy-3a,4,9,9a-tetrahydro-1H-benzo[f][2]benzofuran-3-one | |
| Phytochemicals’ class or type of plant extracts | Polyphenol | |
| Source of phytochemicals or plant Extracts | Taxus yunnanensis | |
| Geographical availability | China South-Central, East Himalaya, Laos, Myanmar, Nepal, Philippines, Sulawesi, Sumatera, Tibet, Vietnam | |
| Plant parts | Leaves, Stem, Root, and Barks | |
| Other cancers | Breast cancer | |
| Target gene or protein | p21 , Bcl-2, p53 , Bax, Caspase 3, Caspase 9, Cyclin D1, CDK4 | |
| Gene or Protein evidence | α-Conidendrin significantly induced apoptosis in breast cancer cells via reactive oxygen species generation, upregulation of p53 and Bax, downregulation of Bcl-2, depolarization of mitochondrial membrane potential (MMP), release of cytochrome c from mitochondria, and activation of caspases-3 and -9. α-Conidendrin remarkably inhibited the proliferation of breast cancer cells through induction of cell cycle arrest by upregulating p53 and p21 and downregulating cyclin D1 and CDK4. | |
| Target pathways | ROS- and caspase-dependent mitochondrial pathway | |
| IC50 | NA | |
| Potency | These results suggest that α-conidendrin can be a promising agent for treatment of breast cancer with little or no toxicity against normal cells. | |
| Cell line/ mice model | MCF-7 and MDA-MB-231 | |
| Additional information | In normal cells, reactive oxygen species levels, loss of MMP, release of cytochrome c, mRNA expression of p53, p21, cyclin D1, CDK4, Bax, and Bcl-2 as well as mRNA expression and activity of caspases-3 and -9 were significantly less affected by α-conidendrin compared with cancer cells. | |
| PubChem ID | 457194 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:828374-1 | |
| Safety | NA |