| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1925 | |
| Phytochemical name or plant extracts | Trigohowimine A | |
| PMID | 29658332 | |
| Literature evidence | Compound 1 showed significant inhibitory effects against various human cancer cell lines with IC50 values ranging from 0.82 to 8.53 μM. | |
| IUPAC name | (3bR,9bS)-6-hydroxy-7-(1-hydroxypropan-2-yl)-9b-methyl-1H,3H,3bH,4H,5H,9bH,10H,11H-phenanthro[1,2-c]furan-1,5-dione | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Trigonostemon howii | |
| Geographical availability | Borneo, Hainan, Laos, Malaya, Myanmar, Philippines, Sumatera, Thailand, Vietnam | |
| Plant parts | Leaves and stem | |
| Other cancers | Breast cancer, Leukemia, Liver cancer, Lung cancer, Colon cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 6.26 ± 0.10 μM against MCF-7 | |
| Potency | Compound 1 showed significant inhibitory effects against various human cancer cell lines with IC50 values ranging from 0.82 to 8.53 μM. Compound 1 is Trigohowimine A | |
| Cell line/ mice model | HL-60, SMMC-7721, A-549, MCF-7 and SW480. | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:358018-1 | |
| Safety | NA |