| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-578 | |
| Phytochemical name or plant extracts | Gossypol | |
| PMID | 1746904 | |
| Literature evidence | Since gossypol, a naturally occurring component of cottonseed oil, exhibits a broad spectrum of activities, we have examined it as an antitumor agent on breast cancer. | |
| IUPAC name | 7-(8-formyl-1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)-2,3,8-trihydroxy-6-methyl-4-propan-2-ylnaphthalene-1-carbaldehyde | |
| Phytochemicals’ class or type of plant extracts | Polyphenolic aldehyde | |
| Source of phytochemicals or plant Extracts | Cotton plant | |
| Geographical availability | Aldabra, Andaman Is., Assam, Bangladesh, Bismarck Archipelago, Borneo, Cambodia, Caroline Is., China Southeast, Cocos (Keeling) Is., Comoros, Djibouti, Eritrea, Fiji, Gilbert Is., Hainan, Hawaii, India, Jawa, Kenya, Laccadive Is., Lesser Sunda Is., Line Is., Madagascar, Malaya, Maldives, Maluku, Marianas, Marquesas, Marshall Is., Mauritius, Mozambique, Myanmar, Nansei-shoto, Nauru, New Caledonia, New Guinea, Nicobar Is., Niue, Oman, Philippines, Pitcairn Is., Queensland, Rodrigues, Samoa, Seychelles, Society Is., Solomon Is., South China Sea, Sri Lanka, Sudan, Sulawesi, Sumatera, Taiwan, Tanzania, Thailand, Tonga, Tuamotu, Tubuai Is., Vanuatu, Vietnam, Wake I., Wallis-Futuna Is. | |
| Plant parts | Cotton Seeds, Flowers of Thespesia populnea | |
| Other cancers | Breast cancer, Cervical cancer, Colon cancer, Brain cancer, epidermal cancer , Colon cancer | |
| Target gene or protein | Bcl-2, Bcl-xL | |
| Gene or Protein evidence | Liposomes containing (-)-gossypol-enriched cottonseed oil suppress Bcl-2 and Bcl-xL expression in breast cancer cells." | |
| Target pathways | NA | |
| IC50 | 2.3 μM against MCF-7 | |
| Potency | The (-)-enantiomer of gossypol possesses higher anticancer potency than racemic gossypol in human breast cancer. | |
| Cell line/ mice model | MCF-7, SiHa, Caco -2, HeLa, MCF-7/Adr, T-47D, HS 683, U373, U87 and U138 , C6 , SW-13 , SK-MEL-3, Colo 201 , KB, HT-29 | |
| Additional information | Strong synergistic cytotoxic and apoptotic activity of gossypol with taxanes in MCF-7 cells Inhibits the growth of cervical (SiHa), breast (MCF-7), and colon (Caco-2) cancer cells Exhibits strong inhibitory effect on cellular proliferation in T-47D cells Inhibits both basal and E2-stimulated DNA synthesis in human breast cancer cells.-MCF-7 and MCF-7/Adr cells (-)-GPCSO inhibits MDR1/P-gp expression,inhibits proliferation,suppresses the expression of Bcl-2 in both MCF- 7/Adr and PCHBCECs (-)-GPCSO liposomes down-regulate Bcl-2 and Bcl-xL mRNA expression in MDA-MB-231 cells and PCHBCECs, exhibit tumor-suppressive activity and increase cytotoxicity of paclitaxel (IN VIVO) | |
| PubChem ID | 3503 | |
| Additional PMIDs | 19810142 27186957 18517219 20843265 18553924 7954365 23482766 26620718 1746904 8255144 7596222 12017312 17352222 20514430 21710341 20529838 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:564713-1 | |
| Safety | NA |