| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-842 | |
| Phytochemical name or plant extracts | [10]-gingerol | |
| PMID | 30370858 | |
| Literature evidence | RESULTS: [10]-gingerol was able to inhibit cell adhesion, migration, invasion and to induce apoptosis more effectively in TNBC cells, when compared to non-tumor cells, demonstrating that these mechanisms can be involved in the antitumor and antimetastatic effects of [10]-gingerol, found both in 3D culture and in vivo. | |
| IUPAC name | (5S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)tetradecan-3-one | |
| Phytochemicals’ class or type of plant extracts | Polyphenol | |
| Source of phytochemicals or plant Extracts | Zingiber officinale | |
| Geographical availability | Assam, China South-Central, East Himalaya, India | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | [10]-gingerol was able to inhibit cell adhesion, migration, invasion and to induce apoptosis more effectively in TNBC cells, when compared to non-tumor cells, demonstrating that these mechanisms can be involved in the antitumor and antimetastatic effects of [10]-gingerol, found both in 3D culture and in vivo. | |
| Cell line/ mice model | MDA-MB-231, MDA-MB-468, mouse (4T1, E0771), MCF-7, T47D | |
| Additional information | Our results indicate a potential for this natural compound as an antitumor molecule or as an adjuvant for chemotherapeutics already used in the clinic. | |
| PubChem ID | 168115 | |
| Additional PMIDs | 34206999 23448448 27399668 28315687 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:798372-1 | |
| Safety | NA |