| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-2066 | |
| Phytochemical name or plant extracts | (Z)-ethylidene-4,6-dimethoxycoumaran-3-one (Compound 1) | |
| PMID | 28749106 | |
| Literature evidence | Thus, the present study allowed isolation and identification of a novel cytotoxic natural compound, (Z)-ethylidene-4,6-dimethoxycoumaran-3-one, from plant leaves of P. quadrifolius (Benth.). | |
| IUPAC name | 2-ethylidene-4,6-dimethoxy-1-benzofuran-3-one | |
| Phytochemicals’ class or type of plant extracts | Coumarin | |
| Source of phytochemicals or plant Extracts | Pogostemon quadrifolius | |
| Geographical availability | Assam, Bangladesh, China South-Central, India, Myanmar | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer, Colorectal cancer, Cervical cancer, Leukemia | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 35.9 μM against MCF-7 | |
| Potency | Our pre-clinical study also indicated that compound 1 is particularly active in the acute T cell leukemia cell line (Jurkat E6-1) with potential for application as a chemotherapeutic agent in the future. | |
| Cell line/ mice model | Caco-2, HeLa, THP-1, MCF-7, Jurkat E6-1 | |
| Additional information | The half-maximal inhibitory concentrations for proliferation (IC50) exhibited by compound 1 were 19.4, 23.1, 22.1, 35.9 and 8.32 μM against Caco-2, HeLa, THP-1, MCF-7 and Jurkat E6-1 cancer cell lines, respectively. Further experiments revealed that compound 1 triggered the apoptosis mode of cell death in cancer cell lines. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:454893-1 | |
| Safety | NA |