| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-771 | |
| Phytochemical name or plant extracts | (6E,10E) isopolycerasoidol | |
| PMID | 25946039 | |
| Literature evidence | Taken together, our data demonstrate that (1) and (2) induce intrinsic mitochondrial-mediated apoptosis in human breast cancer cells, which provides the first pharmacological evidence for their future development as anticancer agents. | |
| IUPAC name | (2E,6E)-9-(6-hydroxy-2,8-dimethyl-3,4-dihydrochromen-2-yl)-2,6-dimethylnona-2,6-dienoic acid | |
| Phytochemicals’ class or type of plant extracts | Benzopyran derivative | |
| Source of phytochemicals or plant Extracts | Pseuduvaria monticola | |
| Geographical availability | Malaya, Thailand | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bcl-2 | |
| Gene or Protein evidence | We showed that treatment of both MCF-7 and MDA-MB-231 breast cancer cell lines with (1) and (2) results in the transcriptional down-regulation of BCL2. | |
| Target pathways | BCL2 and p38 MAPK signaling pathways | |
| IC50 | 59 ± 5.1 μM against MCF-7 76 ± 8.5 μM against MDA-MB-231 | |
| Potency | Taken together, our data demonstrate that (1) and (2) induce intrinsic mitochondrial-mediated apoptosis in human breast cancer cells, which provides the first pharmacological evidence for their future development as anticancer agents. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | NA | |
| PubChem ID | 10066980 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:74957-1 | |
| Safety | NA |