| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-772 | |
| Phytochemical name or plant extracts | (6E,10E) Isopolycerasoidol Methyl Ester | |
| PMID | 25946039 | |
| Literature evidence | Taken together, our data demonstrate that (1) and (2) induce intrinsic mitochondrial-mediated apoptosis in human breast cancer cells, which provides the first pharmacological evidence for their future development as anticancer agents. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Benzopyran derivative | |
| Source of phytochemicals or plant Extracts | Pseuduvaria monticola | |
| Geographical availability | Malaya, Thailand | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 3, Caspase 7, Caspase 9, Bcl-2, p38 MAPK | |
| Gene or Protein evidence | These effects occurred concomitantly with a dose-dependent activation of caspase 3/7 and 9, a down-regulation of the anti-apoptotic gene BCL2 and the accumulation of p38 MAPK in the nucleus. | |
| Target pathways | BCL2 and p38 MAPK signaling pathways | |
| IC50 | 43 ± 2.4μM against MCF-7 58 ± 2.6μM against MDA-MB-231 | |
| Potency | MTT results revealed both (1) and (2) were efficient in reducing cell viability of breast cancer cells. Flow cytometry analysis demonstrated that (1) and (2) induced cell death via apoptosis, as demonstrated by an increase in phosphotidylserine exposure. Both compounds elevated ROS production, leading to reduced mitochondrial membrane potential and increased plasma membrane permeability in breast cancer cells. | |
| Cell line/ mice model | MCF-7,MDA-MB-231 | |
| Additional information | Collectively, our data demonstrate that both (1) and (2) increase membrane permeability, decrease MMP and activate caspases involved in the intrinsic apoptosis pathway in breast cancer cells by modulating BCL2 and p38 MAPK signaling molecules | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:74957-1 | |
| Safety | NA |