| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1693 | |
| Phytochemical name or plant extracts | (3S)-7-hydroxy-8,2′,4′-trimethoxyisoflavane | |
| PMID | 31487934 | |
| Literature evidence | In this study, four novel isoflavanes (1-3 and 5) and four known analogues (4 and 6-8) were isolated from an ethanolic extract of the rattans of S. suberectus. | |
| IUPAC name | (3S)-3-(2,4-dimethoxyphenyl)-8-methoxy-3,4-dihydro-2H-1-benzopyran-7-ol | |
| Phytochemicals’ class or type of plant extracts | Isoflavane | |
| Source of phytochemicals or plant Extracts | Spatholobus suberectus | |
| Geographical availability | Assam, China South-Central, China Southeast, East Himalaya, Laos, Thailand, Vietnam | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 59.0 ± 8.1 μM against MCF-7 >100 μM against MDA-MB-231 | |
| Potency | Interestingly, compounds 1 and 2 only inhibited the proliferation of MCF-7 cells, while compound 6 showed a selective cytotoxicity against MDA-MB-231 cells. However, compound 4 had significant cytotoxicity against both MCF-7 and MDA-MB-231 cell lines. Compound 1 is (3S)-7-hydroxy-8,2′,4′-trimethoxyisoflavane. | |
| Cell line/ mice model | MCF-7, MD-MB-231 | |
| Additional information | Inhibits the proliferation of MCF-7 cells | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:519185-1 | |
| Safety | NA |